Avoiding Hand Dermatitis

Hand dermatitis is one of the most common problems encountered in dermatology with a prevalence possibly as high as 50% hand dermatitisor greater in certain occupations. The dis­comfort associated with hand der­matitis frequently results in a de­creased quality of life. In fact, hand dermatitis can be debilitating for many years.

Dermatitis (or eczema) is inflam­mation of the skin, characterized by itchy (pruritic), red, weeping skin with vesicles and/or crusty patches. The risk factors for hand dermatitis include chemical expo­sures, frequent handwashing, and wet-work environments contribut­ing to a higher prevalence in specif­ic occupations including healthcare professionals, machinists, hair­dressers, and food industry em­ployees.

Several of the extraordinary small molecules found in Viniferamine® skincare products have potent an­ti-inflammatory activities including the beneficial polyphenols oleuro­pein, resveratrol, and epigallocate­chin-3-gallate (EGCG) from olives, grapes, and green tea, respective­ly, as well as the important small molecules, melatonin, and L-glu­tathione. In addition, dipotassium glycyrrhizinate and components of shea butter also possess anti-in­flammatory activities.

Three of the most common types of hand der­matitis include atopic derma­titis (AD), al­lergic contact dermatitis (ACD) and ir­ritant contact dermatitis (ICD). AD is the most com­mon chronic inflammatory skin disease that often occurs in association with food allergies, hay fever or asthma. It affects approximately 15-30% of individuals in the early years of life with a lifetime prevalence of approximately 10-20%. AD is char­acterized by immune dysregulation and epidermal barrier dysfunc­tion caused by genetic mutations in a structural protein (filaggrin) essential for the formation of the skin barrier as well as natural skin moisturizers. A decreased content of specific lipids (ceramides) in the epidermis is also typical of AD. Due to their impaired skin barrier func­tion, individuals with AD are more likely to develop ACD and ICD. AD has also been associated with obe­sity and exposure to air pollutants including tobacco smoke.

ACD is a delayed hypersensitivity response that occurs when an al­lergen comes in contact with the skin. Inflammation is usually de­layed by a few days from the time of exposure. Contact allergens do not produce immune responses by themselves but must bind to epi­dermal proteins in order to elicit a response. Hundreds of chemicals present in almost every industry including metals, resins, and rub­ber additives have been found to cause ACD, which is the second most commonly reported occupa­tional illness. Frequent water ex­posure increases sensitization to allergens, making ACD more com­mon in occupations where wet-work is combined with exposure to allergens.

ICD is an inflammatory response that results from activated innate immunity to skin damage without prior sensitization. The severity of ICD is proportional to the nature of the irritant and the extent of damage to the skin barrier. Organ­ic solvents including acetone can extract lipids from the top layer of the epidermis (stratum corneum) disrupting the skin barrier. In con­trast, detergents like sodium lauryl sulfate (SLS) can damage structural proteins, including keratin, expos­ing new water binding sites, caus­ing hyper-hydration of the stratum corneum and disorganization of the lipid bilayers.

Olives, Green Tea, Grapes Viniferamine® skincare products include ingredients that enhance epidermal barriers. Measuring transepidermal water loss (TEWL) is one way to assess the quality of the skin barrier and how well it functions. Oleuropein has been shown to reduce transepidermal water loss indicating its ability to increase skin barrier function. Evidence also demonstrates that melatonin has a stimulatory role in building and maintaining the epidermal barrier. In addition, di­potassium glycyrrhizinate protects against degradation of hyaluron­ic acid, which helps maintain skin hydration. Viniferamine® skincare products protect epidermal barri­ers. Unlike soaps that may include harsh detergents, Viniferamine® Clean N Moist includes phospho­lipids, nutrients and moisturizers to gently cleanse and protect skin. Furthermore, the dimethicone found in Viniferamine® Silicone Barrier provides a breathable bar­rier to protect skin and help keep it hydrated.

Specific genetic, immune, and envi­ronmental factors predispose indi­viduals to an increased risk of hand dermatitis. Protecting skin by using Viniferamine® Renewal Moisturiz­er, Clean N Moist, and Silicone Bar­rier will enhance the skin barrier to help defend against allergens and irritants. Moreover, many of the potent small molecule ingredients that are included in Viniferamine® skincare products protect against inflammation. Additionally, Vinif­eramine® Hydrocortisone Cream 1% can provide fast, temporary relief of symptoms associated with minor skin irritations and rash.


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Disclaimer: These statements have not been reviewed by the FDA. The decision to use these products should be discussed with a trusted healthcare provider. The authors and the publisher of this work have made every effort to use sources believed to be reliable to provide 
information that is accurate and com­patible with the standards generally accepted at the time of publication. The authors and the publisher shall not be liable for any special, consequential, or exemplary damages resulting, in whole or in part, from the readers’ use of, or reliance on, the information contained in this article. The publisher has no responsibility for the persistence or accuracy of URLs for external or third party Internet websites referred to in this publication and does not guarantee that any content on such websites is, or will remain, accurate or appropriate.


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