Antioxidants and Skin Health

The skin is the largest organ of the body and is the first line of defense against balancing rocksvarious external threats including temperature
changes, dehydration, invading microbes, harmful chemicals, pollution, and ionizing radiation. These threats are potentially damaging because they can alter biological homeo­stasis (or the maintenance and regulation of stability required for proper functioning).

One very important aspect of skin homeostasis involves maintain­ing the balance between the pro­duction of free radicals, known as reactive oxygen species (ROS), and the skin’s oxidative defense system. Toxic chemicals, pollu­tion (including cigarette smoke), ionizing radiation (including UV), and extreme temperature change can all cause elevated ROS that may disrupt this balance, poten­tially leading to oxidative stress, skin inflammation, increased ag­ing and disease.

The natural mechanisms that protect skin from oxidative stress include the production of protec­tive molecules such as melanin and vitamin D, and antioxidant enzymes such as superoxide dis­mutase (SOD) and glutathione peroxidase. However, when these defense mechanisms are over­whelmed, oxidative stress can oc­cur. Oxidative stress is associated with inflammation and is thought to play an important role in skin disorders including atopic der­matitis, eczema, and psoriasis, as well as in impaired wound heal­ing.

Viniferamine® skin and wound care products contain potent an­tioxidants that help prevent or decrease oxidative stress includ­ing resveratrol from grapevine extract, EGCG from green tea ex­tract, and oleuropein from olive leaf extract.

Grapevine (Vitis vinifera) ExtractThe polyphenol, resveratrol, pro­tects against oxidative damage by enhancing the expression of anti­oxidant genes including heme ox­ygenase-1 and glutamate-cysteine ligase. Resveratrol has also been shown to stimulate the antioxi­dant Nrf2 pathway. In fact, stud­ies have demonstrated protec­tive effects of resveratrol against UV radiation-mediated oxidative stress. In addition, resveratrol has been shown to be anti-inflam­matory and capable of promoting diabetic wound healing.

Epigallocatechin-3-gallate (EGCG), a polyphenol from green tea, is thought to scavenge free radicals and is protective against UV-induced oxidative stress and damage. In addition, EGCG is anti-inflammatory and evidence suggests that EGCG is beneficial in wound healing.

The olive polyphenol, oleuropein, has free radical scavenging activi­ties and inhibits increases in ROS induced by UVB irradiation. Oleu­ropein is also an anti-inflammato­ry agent, and has been reported to reduce irradiation-induced er­ythema. Furthermore, evidence suggests that oleuropein acceler­ates wound healing.

All three of these natu­ral polyphe­nols activate FOXO3a, a pro­tein that turns on cellular ox­idative defense enzymes that are part of the body’s intrin­sic protective mechanisms.

In addition, Viniferamine® skin and wound care products con­tain other powerful antioxidants including methylsulfonylmethane mela­tonin and L-glutathione that also enhance skin protection against oxidative stress to help skin main­tain homeostasis. Viniferamine® skin and wound care products in­clude these amazingly beneficial and powerful antioxidants to help skin, the first line of the body’s defense, function at its best.

References

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  5. Free Rad Biol Med 2015; 78: 213-223.
  6. ISRN Endocrinol 2014; ID816307.
  7. Mini Rev Med Chem 2011; 1200-1215.
  8. J Am Acad Dermatol 2005; 52: 1049-1059.
  9. Int J Cosmet Sci 2008; 30: 113-120.
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Disclaimer: These statements have not been reviewed by the FDA. The decision to use these products should be discussed with a trusted healthcare provider. The authors and the publish­er of this work have made every effort to use sources believed to be reliable to provide information that is accurate and com­patible with the standards generally accepted at the time of publication. The authors and the publisher shall not be liable for any special, con­sequential, or exemplary damages resulting, in whole or in part, from the readers’ use of, or reliance on, the information contained in this article. The publisher has no responsibil­ity for the persistence or accuracy of URLs for external or third party Internet websites referred to in this publication and does not guarantee that any content on such websites is, or will remain, accurate or appropri­ate.

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