TECA is a precise blending of three bioactive molecules found in Centella Asiatica. When these molecules (Asiaticoside and Madecassic acid and Asiatic acid) are combined in constant proportions to form a substance with consistently optimal activity, the combination is referred to as titrated extract of Centella Asiatica (TECA). Evidence suggests that titrated extracts of Centella Asiatica can produce different effects in response to various phases of wound repair, with significant wound healing activity found in normal as well as delayed healing models, including animal models of diabetes. Asiaticoside has been reported to promote wound-healing activity by increasing collagen formation and angiogenesis, as well as increasing cellular proliferation at wound sites. In another study, asiatic acid, madecassic, and asiaticoside each were able to stimulate collagen synthesis from human fibroblasts. Asiatic acid has been shown to inhibit UVA-induced reactive oxygen species (ROS) production and lipid peroxidation in human keratinocytes. In addition, asiaticoside has been reported to induce elevation of antioxidant levels at the initial stages of wound healing. Scientific studies also suggest that asiatic acid and madecassic acid have important pro-apoptotic and anti-inflammatory effects. Only the pharmaceutical grade, titrated extract of Centella Asiatica, has been shown to treat burns, scars, wounds, and reduce wrinkles. TECA is considered to have “astonishing” curative properties for skin health.
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