Since the beginning of grape cultivation in the Middle East thousands of years ago, grapes have been thought of as a source of wellness and longevity. Many of the health benefits of grapes are also found in the vine. Grapevine extract contains significant levels of stilbenes including trans-resveratrol, which is proven to have protective effects against a number of skin disorders. Resveratrol is also reported to have potent antioxidant activities, including activities against ultraviolet radiation-mediated oxidative stress. In addition, resveratrol has been discovered to inhibit UVB-mediated skin edema and inflammation, and in an in vitro study, resveratrol was able to block the activation of the NFkB inflammatory pathway in normal human epidermal keratinocytes. Research has also shown that resveratrol can suppress the proliferation of keloid fibroblasts in benign (non-cancerous) skin tumors that sometimes form during wound healing.
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