Skin is made up of mostly proteins and lipids with one very important exception; hyaluronic acid is the only carbohydrate found in the matrix surrounding cells. Most have heard this term and seen its addition to expensive cosmetics. However, hyaluronic acid is a big molecule and cannot penetrate the skin. As people age, and during the healing of wounds, an enzyme is activated that attacks hyaluronic acid and robs cells of the moisture they need to migrate. Dipotassium glycyrrhizinate is the ultimate protector of hyaluronic acid. It has been scientifically demonstrated that dipotassium glycyrrhizinate reduces the damage caused by the destructive enzyme, hyaluronidase. Youthful skin requires proper migration of cells; dipotassium glycyrrhizinate is the most potent ingredient available proven to improve cell migration. It also has important antioxidant and anti-inflammatory activity, and has been used to treat acute and chronic dermatitis. Inhibition of hyaluronidase plays an important role not only in maintaining the hyaluronic acid level in the body but also in anti-inflammatory and anti-allergic activities. This enzyme is activated during inflammation, plays a role in the destruction of the connective tissue matrix, and increases the permeability of inflammatory cells and blood vessels.
1. Evid Based Complement Alternat Med 2012; 2012: 1-9.
2. Int J Pharm 2002; 241 (2): 319-327.
3. Phytomedicine 2012; 19 (7): 658-664.
4. Curr Med Chem 2009; 16 (18): 2261-2288.